Search Result

Results for "

5-HT (5-hydroxytryptamine)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (17) COX (1) Dopamine Receptor (3) Endogenous Metabolite (1) Transthyretin (TTR) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (13)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: 5-HT Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0122

5-Hydroxytryptophan 1 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Endogenous Metabolite	Metabolic Disease
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-19358

2-Methyl-5-HT 2-Methyl-5-hydroxytryptamine; 2-Methylserotonin; 2-Me-5-HT
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects .

HY-103134

SB 204070A	Others	Inflammation/Immunology
5-HT4 antagonist 3 hydrochloride is a highly selective 5-hydroxytryptamine receptor (5-HT₄) antagonist. 5-HT4 antagonist 3 (hydrochloride) blocks muscarine receptors and sodium channels. 5-HT4 antagonist 3 (hydrochloride) can be used to evaluate function of 5-HT₄ receptor .

HY-103139

Altanserin hydrochloride	Others	Metabolic Disease
Altanserin is a 5-hydroxytryptamine (5-HT_2A ) selective radioligand. Altanserin delivers human serotonin. Altanserin can be used to study the biochemical and cellular mechanisms of vulnerability to extracellular 5-HT increase .

HY-19358A

2-Methyl-5-HT hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride; 2-Methylserotonin hydrochloride; 2-Me-HT hydrochloride
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects .

HY-19358B

2-Methyl-5-HT maleate 2-Methyl-5-hydroxytryptamine maleate; 2-Methylserotonin maleate; 2-Me-HT maleate	5-HT Receptor	Neurological Disease
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT maleate is shown to display anti-depressive-like effects .

HY-10351A

Robalzotan hydrochloride NAD-299 hydrochloride	5-HT Receptor	Neurological Disease
Robalzotan hydrochloride (NAD-299 hydrochloride) is a potent and selective **5-Hydroxytryptamine 1A (5-HT1A)** inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system .

HY-111200

Vabicaserin hydrochloride 2 Publications Verification SCA 136	5-HT Receptor	Neurological Disease
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT_2C) receptor-selective agonist with an EC₅₀ of 8 nM.

HY-129101

(-)-Eseroline fumarate Eseroline fumarate	5-HT Receptor	Neurological Disease
(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum .

HY-19889

JNJ-18038683

JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT₇) receptor antagonist, with pK_is of 8.19, 8.20 for rat and human 5-HT₇ in HEK293 cells, respectively.

JNJ-18038683
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT₇) receptor antagonist, with pK_is of 8.19, 8.20 for rat and human 5-HT₇ in HEK293 cells, respectively.

HY-15472

PRX-08066	5-HT Receptor	Cardiovascular Disease
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.

HY-15472A

PRX-08066 maleate	5-HT Receptor	Cardiovascular Disease
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.

HY-14431

Cerlapirdine 1 Publications Verification SAM-531; PF-05212365	5-HT Receptor	Neurological Disease
Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has the potential for researching the Alzheimer's disease .

HY-14441

ML 10302	5-HT Receptor	Neurological Disease
ML 10302 is a potent agonist *5-HT4* receptor with K_i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases .

HY-10349A

WAY-100635 maleate 4 Publications Verification	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 maleate has pIC₅₀ values for *5-HT1A* and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D₄ receptor agonist .

HY-10349

WAY-100635 4 Publications Verification	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 is a potent and selective 5-HT_1A Receptor antagonist with a pIC₅₀ of 8.87, an apparent pA₂ of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 has pIC₅₀ values for *5-HT1A* and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D₄ receptor agonist .

HY-N1957

Gamma-Mangostin 1 Publications Verification γ-Mangostin	5-HT Receptor COX Transthyretin (TTR)	Metabolic Disease Inflammation/Immunology Cancer
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes ^[5].

HY-103116

DV-7028 hydrochloride

5-HT Receptor Cardiovascular Disease

DV-7028 is a selective 5-hydroxytryptamine₂ (5-HT₂) receptor antagonist .

DV-7028 hydrochloride	5-HT Receptor	Cardiovascular Disease
DV-7028 is a selective 5-hydroxytryptamine₂ (5-HT₂) receptor antagonist .

HY-103090

NPS ALX Compound 4a	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-103090A

NPS ALX Compound 4a dihydrochloride	5-HT Receptor	Neurological Disease
NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine₆ (5-HT₆) receptor antagonist, with an IC₅₀ of 7.2 nM and a K_i of 0.2 nM .

HY-103104

Fananserin RP 62203	5-HT Receptor Dopamine Receptor	Neurological Disease
Fananserin (RP 62203) is an orally bioavailable, potent and selective **5-hydroxytryptamine2 (5-HT₂) receptor antagonist, with a K_i** of 0.37 nM for the rat 5-HT_2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a K_i of 2.93 nM for the human dopamine D4 receptor .

HY-121653

Flesinoxan	5-HT Receptor	Neurological Disease
Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC₅₀ value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects .

HY-135507

NAS-181	5-HT Receptor	Neurological Disease
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an K_i value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions .

5-Hydroxytryptophan 1 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

Gamma-Mangostin 1 Publications Verification γ-Mangostin	Structural Classification Xanthones Classification of Application Fields Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Metabolic Disease Plants Disease Research Fields	5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes ^[5].

Species:	Human (3)
Tag:	His (3) SUMO (1)
Source:	E. coli Cell-free (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702328

	HTR7 Protein, Human (Cell-Free, His) 5-hydroxytryptamine receptor 7; 5-HT-X; Serotonin receptor 7	Human	E. coli Cell-free
	The HTR7 protein is a serotonin receptor that coordinates the activity of adenylyl cyclase by activating its G protein. This highlights the critical role of HTR7 in transducing signals initiated by serotonin, affecting multiple physiological processes regulated by the cyclic AMP signaling pathway. HTR7 Protein, Human (Cell-Free, His) is the recombinant human-derived HTR7 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of HTR7 Protein, Human (Cell-Free, His) is 479 a.a., with molecular weight of 56.4 kDa.

HY-P701628

	5HT1B Protein, Human (Cell-Free, His) HTR1B; 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B	Human	E. coli Cell-free
	The 5HT1B protein is a G-protein-coupled receptor for serotonin, ergot alkaloids, and psychoactive substances that undergoes conformational changes upon ligand binding, modulating downstream effectors and inhibiting adenylyl cyclase activity. Inhibin inhibits G protein signaling and activates alternative pathways. 5HT1B Protein, Human (Cell-Free, His) is the recombinant human-derived 5HT1B protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of 5HT1B Protein, Human (Cell-Free, His) is 390 a.a., .

HY-P702324

	HTR1B Protein, Human (Cell-Free, His, SUMO) 5-hydroxytryptamine receptor 1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B	Human	E. coli Cell-free
	The 5HT1B protein is a G-protein-coupled receptor for serotonin, ergot alkaloids, and psychoactive substances that undergoes conformational changes upon ligand binding, modulating downstream effectors and inhibiting adenylyl cyclase activity. Inhibin inhibits G protein signaling and activates alternative pathways. HTR1B Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived HTR1B protein, expressed by E. coli Cell-free , with N-10*His, N-SUMO labeled tag. The total length of HTR1B Protein, Human (Cell-Free, His, SUMO) is 390 a.a., with molecular weight of 62.1 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

5-HT (5-hydroxytryptamine)

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Antibodies

Natural
Products